US 421

US 421 is the longest running North-South US highway in North Carolina.  Running from the southeast corner of the state, Fort Fisher, and running northwesterly to Tennessee (northwest of Boone), this highway also runs through the city limits of North Wilkesboro, Winston-Salem, Greensboro, Sanford and Wilmington.  Being one of the more important corridors in the state, there are many freeway and expressway segments to this route whether recently opened within the past decade, under construction, or planned for the future.  If you have any additional photos or information for this page, please e-mail me.
National Southern Terminus: Fort Fisher


(Matt Sides)

The route that begins in Michigan City, Indiana has a seaside ending for the southern terminus in Fort Fisher.  US 421 formally ends at the Ft. Fisher-Southport Ferry that connects the two locations by crossing the Cape Fear River.


(Matt Sides)

Standing opposite of the 'END' US 421 shield is a 'BEGIN' North US 421 combination.

Site Navigation:

  • US Highway Ends in NC Index
  • Sources & Links:

  • US 421 @ NCRoads.com Annex ---Mike Roberson
  • US 421 National Ends ---Dale Sanderson
  • US 421 National Ends ---Adam Froehlig
  • North Carolina Ferry System

  • Page Created: September 26, 2004
    Last Updated: September 26, 2004

    (C) 2004 Adam Prince